Gastrointestinal satiety signals

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Gastrointestinal satiety signals II. Cholecystokinin.

During a meal, ingested nutrients accumulate in the stomach, with a significant portion passing on to the small intestine. The gastrointestinal presence of ingested nutrients initiates a range of physiological responses that serve to facilitate the overall digestive process. Thus peptides and transmitters are released, and various neural elements are activated that coordinate gastrointestinal s...

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The focus of this article is to review evidence that apolipoprotein A-IV (apo A-IV) acts as a satiety factor. Additionally, information regarding the general involvement of apo A-IV in the regulation of food intake and body weight is stated. Apo A-IV is a glycoprotein synthesized by the human intestine. In rodents, both the small intestine and liver secrete apo A-IV, but the small intestine is ...

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Gastrointestinal satiety signals I. An overview of gastrointestinal signals that influence food intake.

An overview is presented of those signals generated by the gastrointestinal (GI) tract during meals that interact with the central nervous system to create a sensation of fullness and satiety. Although dozens of enzymes, hormones, and other factors are secreted by the GI tract in response to food in the lumen, only a handful are able to influence food intake directly. Most of these cause meals ...

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Gastrointestinal satiety signals III. Glucagon-like peptide 1, oxyntomodulin, peptide YY, and pancreatic polypeptide.

Many peptides are synthesized and released from the gastrointestinal tract and pancreas, including pancreatic polypeptide (PP) and the products of the gastrointestinal L cells, glucagon-like peptide 1 (GLP-1), oxyntomodulin, and peptide YY (PYY). Whereas their roles in regulation of gastrointestinal function have been known for some time, it is now evident that they also influence eating behavi...

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Gastrointestinal satiety in animals other than man.

The present paper reviews the development of some of our ideas of how physiological stimuli on the gastrointestinal tract contribute to the onset of satiety. The various signals originating from the gut caused by stretch, osmo-concentration or specific chemical stimuli must be relayed to the brain, either neurally or hormonally, to be integrated with post-absorptive signals from other sites inc...

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ژورنال

عنوان ژورنال: International Journal of Obesity

سال: 2008

ISSN: 0307-0565,1476-5497

DOI: 10.1038/ijo.2008.235